Guide to PET modelling

Introduction

1. PET data
2. Why model?

Model development

1. Tracer selection
2. Comprehensive model
3. Workable model
4. Model validation
5. Model application

Simplification of studies

1. Static imaging
2. Macroparameters
3. No blood sampling

Models for analyzing PET data

1. Compartmental models
2. Reference tissue compartmental models
3. Generalized compartmental modeling approaches
   • Multiple-time graphical analysis: Logan plot and Gjedde-Patlak plot
   • Spectral analysis
   • Transient equilibrium
   • Bolus+infusion
   • Autoradiography
4. Distributed models

Which model to use?

Additional reading:

• PET tracers
• Modelling reports
• Vocabulary